Poison bottles have an interesting history.  Over the centuries as man has explored the chemical and medical nature of poisonous substances thousand have died by accidentally ingesting the contents of an unmarked bottle.  In Greek times, Methridates VI, King of Pontus from about 120 to 63 B.C. was said to have been one of the first to raise the art poisoning  and counteracting poisons to a high level.  Throughout the ages poisoning members of the royal court was a common practice.  Eventually apothecaries and druggists began marking bottles by labeling them as poisonous, but the presence of so many dangerous chemicals in households in the 19th century gave rise to a new practice of creating distinctive bottles in which to store poisons.  Most involved the use of raised ridges, dots, diamonds or other design to alert the unwary to the potential danger simply by feel.  The use of the skull and crossbones is a rather recent occurrence and is not found on bottles until about the 1880-1890 period. Increasingly, states passed laws concerning the sale distribution of poisonous substances.  The Design Patents below show some of the bottles which today are eagerly sought after by poison bottle collectors.

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1893 Design Patent

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English 1894

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1902 Bee Design

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1906 Lilly

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1908 Rattlesnake

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Whithall Tatum and United Drug Company